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More than 30% reported the craniofacial (scalp/face), groin, or inframammary (region beneath breasts) regions. Because many respondents reported more than one region of involvement rates add up to a figure well above 100%. For example 81% and 46% of individuals reported hyperhidrosis in 3+ and 4+ regions respectively.
Interestingly, 89% of individuals over the age of 65 years reported their sweating has stayed the same or become worse over the years. This finding dispels the notion that focal hyperhidrosis regresses over time and that its prevalence is relatively low among older adults.
*Dermatol Surg 2016;42:1347-53
In the past, several studies have demonstrated that the volume or number of sweat glands is no different in individuals with hyperhidrosis than in those without the condition. Having said this, the new study has demonstrated that a protein called Aquaporin 5 is overexpressed in hyperhidrosis. In other words, the gene that codes for this protein is more productive or generates a greater number of Aquaporin protein copies.
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